{"id":37087,"date":"2021-01-21T12:55:47","date_gmt":"2021-01-21T12:55:47","guid":{"rendered":"https:\/\/allaboutibs.com\/gastrointestinalne-problemy-s-covid-19\/"},"modified":"2023-04-28T13:08:43","modified_gmt":"2023-04-28T13:08:43","slug":"gastrointestinalne-problemy-s-covid-19","status":"publish","type":"post","link":"https:\/\/allaboutibs.com\/sk\/gastrointestinalne-problemy-s-covid-19\/","title":{"rendered":"Gastrointestin\u00e1lne probl\u00e9my s COVID-19"},"content":{"rendered":" \n

Nov\u00fd koronav\u00edrus (SARS-CoV-2) sa v s\u00fa\u010dasnosti \u0161\u00edri po celom svete a ovplyv\u0148uje n\u00e1s r\u00f4znymi sp\u00f4sobmi. Denne \u010d\u00edtame o v\u0161etk\u00fdch tragick\u00fdch \u00famrtiach a v\u00e1\u017ene chor\u00fdch \u013eu\u010foch, ale na\u0161\u0165astie sa v\u00e4\u010d\u0161ina \u013eud\u00ed postihnut\u00fdch v\u00edrusom zotav\u00ed. Typick\u00fdmi pr\u00edznakmi v\u00edrusu s\u00fa such\u00fd ka\u0161e\u013e, hor\u00fa\u010dka a d\u00fdchavi\u010dnos\u0165, ale uk\u00e1zalo sa, \u017ee pri COVID-19 sa \u010dasto vyskytuj\u00fa aj gastrointestin\u00e1lne probl\u00e9my.<\/p> \n \n

Be\u017en\u00e9 gastrointestin\u00e1lne probl\u00e9my spojen\u00e9 s COVID-19<\/h2> \n \n

V \u010dasopise The British Medical Journal bol ned\u00e1vno uverejnen\u00fd preh\u013ead 20 133 pacientov lie\u010den\u00fdch v nemocniciach Spojen\u00e9ho kr\u00e1\u013eovstva (1). V tomto \u010dl\u00e1nku sa uv\u00e1dza, \u017ee pri COVID-19 s\u00fa be\u017en\u00e9 r\u00f4zne pr\u00edznaky z gastrointestin\u00e1lneho traktu, ako napr\u00edklad boles\u0165 brucha, hna\u010dka a vracanie.<\/p> \n \n

Hna\u010dkou trpelo 20,4 % (22,0 % \u017eien a 19,3 % mu\u017eov) a nevo\u013enos\u0165ou\/vracan\u00edm 19,8 % (23,5 % \u017eien a 17,3 % mu\u017eov).<\/p> \n \n

Tieto pr\u00edznaky sa tak dostali do prvej desiatky (na 8. a 9. miesto) medzi naj\u010dastej\u0161ie pr\u00edznaky COVID-19, aspo\u0148 u t\u00fdch, ktor\u00ed boli o\u0161etrovan\u00ed v nemocniciach v Spojenom kr\u00e1\u013eovstve. Boles\u0165 brucha sa umiestnila na 13. mieste medzi naj\u010dastej\u0161\u00edmi pr\u00edznakmi a postihovala 10,2 % (11,4 % \u017eien a 9,3 % mu\u017eov).<\/p> \n \n

\n
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Gastrointestinal problems such as diarrhea, nausea and vomiting are common symptoms of COVID-19 according to a study of over 20,000 patients from various hospitals in the UK (1). The figure shows the proportion of patients who presented the respective symptoms.<\/p><\/div> \n \n<\/figure> \n \n

Niekedy s\u00fa jedin\u00fdmi pr\u00edznakmi gastrointestin\u00e1lne probl\u00e9my<\/h2> \n \n

Zoznam r\u00f4znych pr\u00edznakov je dlh\u00fd a nie je mo\u017en\u00e9, aby sa u toho ist\u00e9ho pacienta vyskytli v\u0161etky pr\u00edznaky v rovnakom \u010dase. Preva\u017en\u00e1 v\u00e4\u010d\u0161ina (pribli\u017ene 70 %) mala st\u00e1le jeden alebo viacero be\u017en\u00fdch pr\u00edznakov: hor\u00fa\u010dku, ka\u0161e\u013e a\/alebo d\u00fdchavi\u010dnos\u0165.<\/p> \n \n

Za\u010diatkom tohto roka sa v inej, podstatne men\u0161ej \u0161t\u00fadii so 74 pacientmi z \u010c\u00edny zistilo, \u017ee u 21 pacientov (28,38 %) sa prejavili len pr\u00edznaky z gastrointestin\u00e1lneho traktu v podobe nevo\u013enosti, vracania a\/alebo hna\u010dky (2). T\u00edto pacienti nemali be\u017en\u00e9 pr\u00edznaky, ako je ka\u0161e\u013e, ale napriek tomu mali COVID-19 (infekcia SARS-Cov-2). M\u00f4\u017ee by\u0165 \u0165a\u017ek\u00e9 porovna\u0165 r\u00f4zne \u0161t\u00fadie z r\u00f4znych kraj\u00edn a r\u00f4znych situ\u00e1ci\u00ed, ale v ka\u017edom pr\u00edpade sa zd\u00e1, \u017ee m\u00f4\u017eete ma\u0165 v\u00edrusov\u00e9 ochorenie a len ur\u010dit\u00e9 pr\u00edznaky z gastrointestin\u00e1lneho traktu.<\/p> \n \n

V\u00edrus zost\u00e1va v stolici dlh\u00fd \u010das<\/h2> \n \n

Nieko\u013eko \u0161t\u00fadi\u00ed v\u0161ak tie\u017e uk\u00e1zalo, \u017ee aj u t\u00fdch, ktor\u00ed nemaj\u00fa \u017eiadne probl\u00e9my v tr\u00e1viacom trakte, sa v\u00edrus \u010dasto nach\u00e1dza v stolici. Na pos\u00fadenie v\u00fdvoja infekcie bolo dokonca mo\u017en\u00e9 pou\u017ei\u0165 vzorky z odpadov\u00fdch v\u00f4d.<\/p> \n \n

Endoskopia uk\u00e1zala, \u017ee v\u00edrus sa m\u00f4\u017ee vyskytova\u0165 na r\u00f4znych miestach tr\u00e1viaceho traktu, ako je pa\u017eer\u00e1k, \u017eal\u00fadok, dvan\u00e1stnik a kone\u010dn\u00edk. Zd\u00e1 sa tie\u017e, \u017ee v\u00edrus m\u00f4\u017ee zosta\u0165 v tr\u00e1viacom trakte ur\u010dit\u00fd \u010das, aj ke\u010f opustil d\u00fdchacie cesty. V jednej \u0161t\u00fadii mala polovica pacientov v\u00edrus v stolici 11 dn\u00ed po tom, ako boli vzorky z d\u00fdchac\u00edch ciest negat\u00edvne na pr\u00edtomnos\u0165 v\u00edrusu (4).<\/p> \n \n

V\u00edrus sa dostane do buniek<\/h2> \n \n

Je zn\u00e1me, \u017ee v\u00edrus vstupuje do buniek cez receptor (receptor na bunk\u00e1ch) naz\u00fdvan\u00fd ACE2. Tento receptor sa nach\u00e1dza v \u010drev\u00e1ch a podie\u013ea sa na regul\u00e1cii z\u00e1palu. Zd\u00e1 sa, \u017ee bunky v tr\u00e1viacom trakte maj\u00fa aj in\u00e9 vlastnosti, ktor\u00e9 umo\u017e\u0148uj\u00fa v\u00edrusu prenikn\u00fa\u0165 do nich. Bunky v tr\u00e1viacom trakte, podobne ako bunky v p\u013e\u00facach, okrem in\u00e9ho produkuj\u00fa ur\u010dit\u00e9 enz\u00fdmy, ktor\u00e9 v\u00edrus potrebuje na napadnutie buniek.<\/p> \n \n

COVID-19 a IBD<\/h2> \n \n

S\u00favislos\u0165 medzi v\u00edrusom a z\u00e1palom v \u010drev\u00e1ch vyvolala ot\u00e1zku, \u010di \u013eudia so z\u00e1palov\u00fdm ochoren\u00edm \u010driev (IBD Crohnova choroba a ulcer\u00f3zna kolit\u00edda) m\u00f4\u017eu by\u0165 vystaven\u00ed v\u00edrusu viac ako ostatn\u00ed v d\u00f4sledku zmenenej expresie receptora ACE2 v \u010drev\u00e1ch v d\u00f4sledku z\u00e1palu. Na potvrdenie tejto s\u00favislosti je v\u0161ak potrebn\u00fd \u010fal\u0161\u00ed v\u00fdskum. Dnes nie je zn\u00e1me, pre\u010do s\u00fa gastrointestin\u00e1lne probl\u00e9my s COVID-19 tak\u00e9 \u010dast\u00e9, alebo \u010di by gastrointestin\u00e1lny trakt mohol by\u0165 alternat\u00edvnou cestou, ktorou sa v\u00edrus dost\u00e1va do tela. Jednou z ot\u00e1zok, ktor\u00e9 n\u00e1s tr\u00e1pia, je napr\u00edklad to, ako sa v\u00edrus dok\u00e1\u017ee dosta\u0165 cez extr\u00e9mne pH, ktor\u00e9mu je vystaven\u00fd v tr\u00e1viacom trakte. My na alltomibs.com samozrejme sledujeme v\u00fdvoj tohto v\u00edrusu a jeho \u00fa\u010dinky na gastrointestin\u00e1lny trakt.<\/p> \n

Viac inform\u00e1ci\u00ed o gastrointestin\u00e1lnych pr\u00edznakoch a COVID-19 n\u00e1jdete na str\u00e1nke theromefoundation.org<\/a><\/p> \n \n

Referenser<\/h2> \n \n

1 Docherty AB, Harrison EM, Green CA a kol. Charakteristiky 20 133 pacientov v Spojenom kr\u00e1\u013eovstve hospitalizovan\u00fdch s kovidom-19 s pou\u017eit\u00edm protokolu klinickej charakteristiky ISARIC WHO: prospekt\u00edvna observa\u010dn\u00e1 kohortov\u00e1 \u0161t\u00fadia. BMJ<\/em>. 2020;369:m1985. Uverejnen\u00e9 2020 m\u00e1j 22. doi:10.1136\/bmj.m1985 L\u00c4NK<\/a><\/p> \n \n

2 Jin X, Lian JS, Hu JH a kol. Epidemiologick\u00e1, klinick\u00e1 a virologick\u00e1 charakteristika 74 pr\u00edpadov koronav\u00edrusovej infekcie 2019 (COVID-19) s gastrointestin\u00e1lnymi pr\u00edznakmi. \u010crev\u00e1<\/em>. 2020;69(6):1002\u20101009. doi:10.1136\/gutjnl-2020-320926 L\u00c4NK<\/a><\/p> \n \n

3 Ng SC, Tilg H. COVID-19 a gastrointestin\u00e1lny trakt: viac, ako sa zd\u00e1 na prv\u00fd poh\u013ead. Gut.<\/em> 2020;69(6):973-974. doi:10.1136\/gutjnl-2020-321195 L\u00c4NK<\/a><\/p> \n \n

4 Wu Y, Guo C, Tang L a kol. Dlhodob\u00e1 pr\u00edtomnos\u0165 v\u00edrusovej RNA SARS-CoV-2 vo vzork\u00e1ch stolice. Lancet Gastroenterol Hepatol<\/em>. 2020;5(5):434-435. doi:10.1016\/S2468-1253(20)30083-2 L\u00c4NK<\/a><\/p> \n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Nov\u00fd koronav\u00edrus (SARS-CoV-2) sa v s\u00fa\u010dasnosti \u0161\u00edri po celom svete a ovplyv\u0148uje n\u00e1s r\u00f4znymi sp\u00f4sobmi. Denne \u010d\u00edtame o v\u0161etk\u00fdch tragick\u00fdch \u00famrtiach a v\u00e1\u017ene chor\u00fdch \u013eu\u010foch, ale na\u0161\u0165astie sa v\u00e4\u010d\u0161ina \u013eud\u00ed postihnut\u00fdch v\u00edrusom zotav\u00ed. Typick\u00fdmi pr\u00edznakmi v\u00edrusu s\u00fa such\u00fd ka\u0161e\u013e, hor\u00fa\u010dka a d\u00fdchavi\u010dnos\u0165, ale uk\u00e1zalo sa, \u017ee pri COVID-19 sa \u010dasto vyskytuj\u00fa aj gastrointestin\u00e1lne probl\u00e9my. […]<\/p>\n","protected":false},"author":2,"featured_media":36880,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[152],"tags":[],"class_list":["post-37087","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ine-crevne-problemy_sk","et-has-post-format-content","et_post_format-et-post-format-standard"],"yoast_head":"\nGastrointestin\u00e1lne probl\u00e9my s COVID-19 - all about IBS<\/title>\n<meta name=\"description\" content=\"Preva\u017en\u00e1 v\u00e4\u010d\u0161ina (pribli\u017ene 70 %) mala st\u00e1le jeden alebo viacero be\u017en\u00fdch pr\u00edznakov: hor\u00fa\u010dku, ka\u0161e\u013e a\/alebo d\u00fdchavi\u010dnos\u0165.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/allaboutibs.com\/sk\/gastrointestinalne-problemy-s-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gastrointestin\u00e1lne probl\u00e9my s COVID-19 - 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