{"id":38922,"date":"2023-02-17T19:08:39","date_gmt":"2023-02-17T19:08:39","guid":{"rendered":"https:\/\/allaboutibs.com\/je-ibs-geneticka-porucha\/"},"modified":"2024-04-30T09:23:19","modified_gmt":"2024-04-30T09:23:19","slug":"je-ibs-geneticka-porucha","status":"publish","type":"post","link":"https:\/\/allaboutibs.com\/cs\/je-ibs-geneticka-porucha\/","title":{"rendered":"Je IBS genetick\u00e1 porucha?"},"content":{"rendered":"

[et_pb_section fb_built=“1″ _builder_version=“4.16″ global_colors_info=“{}“][et_pb_row _builder_version=“4.16″ background_size=“initial“ background_position=“top_left“ background_repeat=“repeat“ global_colors_info=“{}“][et_pb_column type=“4_4″ _builder_version=“4.16″ custom_padding=“|||“ global_colors_info=“{}“ custom_padding__hover=“|||“][et_pb_text _builder_version=“4.16″ background_size=“initial“ background_position=“top_left“ background_repeat=“repeat“ global_colors_info=“{}“]<\/p>\n

I kdy\u017e je b\u011b\u017en\u00e9, \u017ee pacienti s IBS maj\u00ed p\u0159\u00edbuzn\u00e9, kte\u0159\u00ed trp\u00ed podobn\u00fdmi p\u0159\u00edznaky, d\u011bdi\u010dnost IBS nebyla dosud potvrzena. P\u0159edpokl\u00e1d\u00e1 se, \u017ee rozvoj IBS u p\u0159\u00edbuzn\u00fdch je sp\u00ed\u0161e d\u016fsledkem vystaven\u00ed podobn\u00fdm faktor\u016fm prost\u0159ed\u00ed ve spole\u010dn\u00e9 dom\u00e1cnosti. Vystaven\u00ed stresor\u016fm v dom\u00e1cnosti v ran\u00e9m d\u011btstv\u00ed je spojeno se zv\u00fd\u0161en\u00fdm rizikem vzniku p\u0159\u00edznak\u016f IBS. P\u0159\u00edkladem stresor\u016f jsou fyzick\u00e9 a slovn\u00ed t\u00fdr\u00e1n\u00ed, \u0161patn\u00e9 \u017eivotn\u00ed podm\u00ednky, nemocn\u00ed \u010dlenov\u00e9 rodiny atd. [1 .]<\/p>\n

Pro\u010d je vystaven\u00ed stresor\u016fm rizikov\u00fdm faktorem?<\/h2>\n

Je zn\u00e1mo, \u017ee stres m\u011bn\u00ed slo\u017een\u00ed a r\u016fst st\u0159evn\u00ed mikrofl\u00f3ry a vyvol\u00e1v\u00e1 uvol\u0148ov\u00e1n\u00ed kortizolu – hormonu, kter\u00fd zprost\u0159edkov\u00e1v\u00e1 reakci na stres. Dlouhodob\u00e9 vystaven\u00ed r\u016fzn\u00fdm stresor\u016fm m\u016f\u017ee m\u00edt negativn\u00ed vliv na osu st\u0159evo-mozek. Proto je stres \u010dasto pova\u017eov\u00e1n za jeden ze zdroj\u016f gastrointestin\u00e1ln\u00edch probl\u00e9m\u016f.<\/p>\n

IBS m\u016f\u017ee b\u00fdt zp\u016fsobena genetickou mutac\u00ed<\/h2>\n

Poda\u0159ilo se v\u0161ak identifikovat genetickou mutaci v genu SCN5A. Tato mutace ovliv\u0148uje sod\u00edkov\u00e9 kan\u00e1ly v hladk\u00e9m svalstvu tr\u00e1vic\u00edho traktu. Sod\u00edkov\u00e9 kan\u00e1ly p\u0159isp\u00edvaj\u00ed k norm\u00e1ln\u00ed st\u0159evn\u00ed motilit\u011b<\/strong> – pohybu potravy st\u0159evy. Porucha t\u011bchto kan\u00e1l\u016f zp\u016fsobuje u pacient\u016f s IBS poruchy vyprazd\u0148ov\u00e1n\u00ed. Tato mutace se zat\u00edm vyskytuje asi u 2-3 % pacient\u016f s IBS. [2 .]<\/p>\n

Existuj\u00ed v\u0161ak genetick\u00e9 poruchy, kter\u00e9 napodobuj\u00ed p\u0159\u00edznaky IBS. Mezi nej\u010dast\u011bj\u0161\u00ed pat\u0159\u00ed z\u00e1n\u011btliv\u00e9 st\u0159evn\u00ed onemocn\u011bn\u00ed, Crohnova choroba nebo celiakie. Pro nalezen\u00ed spr\u00e1vn\u00e9 l\u00e9\u010dby je d\u016fle\u017eit\u00e9 tyto diagn\u00f3zy vylou\u010dit.<\/p>\n

Je b\u011b\u017en\u00e9 m\u00edt IBS a d\u011bdi\u010dnou psychickou poruchu?<\/h2>\n

Za \u00favahu stoj\u00ed tak\u00e9 genetika psychiatrick\u00fdch poruch, kter\u00e9 jsou \u010dasto spojeny s p\u0159\u00edznaky IBS. U n\u011bkter\u00fdch pacient\u016f s IBS bylo zji\u0161t\u011bno, \u017ee l\u00e9\u010dba antidepresivy \u00fa\u010dinn\u011b sni\u017euje z\u00e1va\u017enost p\u0159\u00edznak\u016f. Nen\u00ed jasn\u00e9, pro\u010d to funguje, ale pacienti s traumatick\u00fdmi ud\u00e1lostmi v anamn\u00e9ze a pacienti s IBS podtypu D m\u011bli v\u011bt\u0161\u00ed pravd\u011bpodobnost, \u017ee budou na l\u00e9\u010dbu reagovat. [3 .]<\/p>\n

Upozor\u0148ujeme, \u017ee antidepresiva jsou \u010dasto spojena s ne\u017e\u00e1douc\u00edmi vedlej\u0161\u00edmi \u00fa\u010dinky a p\u0159ed volbou l\u00e9\u010dby antidepresivy je t\u0159eba zv\u00e1\u017eit jin\u00e9 typy l\u00e9\u010dby.<\/p>\n

    <\/ol>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=“1″ _builder_version=“4.19.5″ _module_preset=“default“ global_colors_info=“{}“][et_pb_row _builder_version=“4.19.5″ _module_preset=“default“ global_colors_info=“{}“][et_pb_column type=“4_4″ _builder_version=“4.19.5″ _module_preset=“default“ global_colors_info=“{}“][et_pb_image src=“https:\/\/allaboutibs.com\/wp-content\/uploads\/2023\/02\/22B30517-B675-429A-B295-A5F6EA68429F.png“ alt=“Sch\u00e9ma IBS“ title_text=“22B30517-B675-429A-B295-A5F6EA68429F“ _builder_version=“4.19.5″ _module_preset=“default“ global_colors_info=“{}“][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=“1″ _builder_version=“4.19.5″ _module_preset=“default“ global_colors_info=“{}“][et_pb_row _builder_version=“4.19.5″ _module_preset=“default“ global_colors_info=“{}“][et_pb_column type=“4_4″ _builder_version=“4.19.5″ _module_preset=“default“ global_colors_info=“{}“][et_pb_text _builder_version=“4.19.5″ _module_preset=“default“ custom_padding=“||4px|||“ global_colors_info=“{}“]<\/p>\n

    Souhrn<\/h2>\n

    D\u011bdi\u010dnost IBS nebyla dosud potvrzena. P\u0159\u00edznaky IBS u p\u0159\u00edbuzn\u00fdch jsou pravd\u011bpodobn\u011b zp\u016fsobeny spole\u010dn\u00fdmi zku\u0161enostmi.<\/p>\n

    Byla zji\u0161t\u011bna genetick\u00e1 mutace v genu k\u00f3duj\u00edc\u00edm sod\u00edkov\u00e9 kan\u00e1ly, kter\u00e1 zp\u016fsobuje nepravidelnou funkci st\u0159evn\u00ed motility. Odhaduje se, \u017ee tuto mutaci m\u00e1 pouze 2-3 % pacient\u016f s IBS.<\/p>\n

    Riziko vzniku p\u0159\u00edznak\u016f IBS je vy\u0161\u0161\u00ed u pacient\u016f s d\u011bdi\u010dn\u00fdmi psychiatrick\u00fdmi poruchami. Antidepresiva mohou b\u00fdt v ur\u010dit\u00fdch p\u0159\u00edpadech \u00fa\u010dinnou l\u00e9\u010dbou p\u0159\u00edznak\u016f IBS.<\/p>\n

     <\/p>\n

    Odkazy<\/h3>\n
      \n
    1. Saito, Y. A. (2011). \u00daloha genetiky u IBS. Gastroenterology Clinics of North America<\/i>, 40<\/i>(1), 45-67. https:\/\/doi.org\/10.1016\/j.gtc.2010.12.011<\/li>\n
    2. Nalezeno genetick\u00e9 vod\u00edtko k syndromu dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku<\/i>. (2014). ScienceDaily. https:\/\/www.sciencedaily.com\/releases\/2014\/03\/140320173158.htm<\/li>\n
    3. Quigley, E., Craig, O., & Dinan, T. (2011). \u00daloha antidepresiv v l\u00e9\u010db\u011b syndromu dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku (IBS) [Review of The role of antidepressants in the management of irritable bowel syndrome (IBS)<\/i>]. Medicine, Psychology<\/i>, 26<\/i>(2), 140-146.<\/li>\n<\/ol>\n

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      I kdy\u017e je b\u011b\u017en\u00e9, \u017ee pacienti s IBS maj\u00ed p\u0159\u00edbuzn\u00e9, kte\u0159\u00ed trp\u00ed podobn\u00fdmi p\u0159\u00edznaky, d\u011bdi\u010dnost IBS nebyla dosud potvrzena. P\u0159edpokl\u00e1d\u00e1 se, \u017ee rozvoj IBS u p\u0159\u00edbuzn\u00fdch je sp\u00ed\u0161e d\u016fsledkem vystaven\u00ed podobn\u00fdm faktor\u016fm prost\u0159ed\u00ed ve spole\u010dn\u00e9 dom\u00e1cnosti. Vystaven\u00ed stresor\u016fm v dom\u00e1cnosti v ran\u00e9m d\u011btstv\u00ed je spojeno se zv\u00fd\u0161en\u00fdm rizikem vzniku p\u0159\u00edznak\u016f IBS. P\u0159\u00edkladem stresor\u016f jsou fyzick\u00e9 […]<\/p>\n","protected":false},"author":10,"featured_media":38932,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[356],"tags":[412,414,416,404,400,332,407,408],"class_list":["post-38922","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diagnoza","tag-antidepresiva-cs","tag-dedicne-cs","tag-dedicnost-cs","tag-geneticka-porucha-cs","tag-genetika-cs","tag-ibs-cs","tag-mutace","tag-zavada","et-has-post-format-content","et_post_format-et-post-format-standard"],"yoast_head":"\nJe IBS genetick\u00e1 porucha?<\/title>\n<meta name=\"description\" content=\"Je b\u011b\u017en\u00e9, \u017ee pacienti s IBS maj\u00ed p\u0159\u00edbuzn\u00e9, kte\u0159\u00ed trp\u00ed podobn\u00fdmi p\u0159\u00edznaky. 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